Director, Decision Analysis PPM

Location: San Rafael
Posted on: June 23, 2025

Job Description:

Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best – people with the right technical expertise and a relentless drive to solve real problems – and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we’ve produced a diverse pipeline of commercial, clinical and preclinical candidates that have well-understood biology and provide an opportunity to be first-to-market or offer a substantial benefit over existing therapeutic options. About Commercial Our Commercial organization leads our global sales and marketing strategies around the world. Our integrated team continues to solidify BioMarin’s commercial presence in the United States and Europe and is rapidly growing in other regions, such as Latin America, the Middle East and Asia-Pacific. Overview The Portfolio Strategy team plays a critical role in ensuring that portfolio investments are strategic, data-driven, and aligned with corporate priorities. This team operates across research, development and commercial functions to provide structured insights and enable executive decision-making. The Director, Decision Analysis PPM, will be responsible for analyzing data, creating scenarios, and providing recommendations. This individual will tackle complex asset and portfolio investment questions, integrating scientific, financial, and other insights to drive high-impact decisions. As a strategic thought partner, they will ensure that portfolio and asset strategies align with our broader corporate objectives. Responsibilities: Lead efforts to improve decision quality in the organization by developing and continuously improving decision analysis methodologies and best practices. Develop and maintain processes to incorporate uncertainties into asset / portfolio planning and execution. Facilitate uncertainty workshops and incorporate uncertainties into decision analyses. Work with Asset Teams, Program Management Leads, and SMEs to determine planning confidence levels and develop risk-adjusted development timelines and scenarios. Enhance and facilitate processes to estimate pre-clinical and clinical probabilities of success. Develop and maintain multi-criteria scoring models to assess and compare assets. Develop and refine portfolio models that integrate attrition rates, clinical probability of success, timeline uncertainties, and commercial forecast scenarios to inform decision-making. Execute portfolio optimization processes during financial planning cycles. Build, maintain and execute portfolio analysis processes and tools to support strategic decision making. Structure and perform scenario analyses and simulations to model and value strategic alternatives and trade-offs with the aim of maximizing value at an asset and a portfolio level. Provide support to teams for decision framing and decision analysis by demonstrating established methodologies. Qualifications: Bachelor's degree in a scientific or technical field (e.g., Biology, Chemistry, Engineering) or equivalent experience. 10 years of experience in strategy or portfolio management within pharmaceutical/biotech company, or equivalent experience in management consulting or other industry with strong discipline in decision analysis. Ability to perform and synthesize in-depth analyses of asset and portfolio information, integrating findings into insights and actionable recommendations. Demonstrated ability to work cross-functionally across research, clinical development, commercial, and manufacturing teams. Excellent communication, interpersonal, and presentation skills. Strong organizational and problem-solving skills. Ability to work independently and as part of a team. Advanced degree preferred (MS or MBA), with a strong understanding of drug development, R&D strategy, and decision analysis. Skills: Application of various decision analysis methodologies and tools. Portfolio modeling, scenario planning, or strategic investment frameworks using modeling and simulation software (e.g., @Risk, R, Analytica). Business & Financial Acumen: Understanding of business objectives, strategies, and Discounted Cash Flow Analysis. Cross-Functional Collaboration: Working effectively with diverse teams. Communication: Excellent written and verbal communication skills. Flexibility to adapt to changing environment Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

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