Scientist I / II, Functional Genomics, Research

Company: BioMarin Pharmaceutical Inc.
Location: San Rafael
Posted on: January 12, 2020

Job Description:

SummaryWe are seeking a highly motivated,innovativeand team-oriented individual to jointheH umanG enetics researchgroup.Within theH umanG enetics group ,theF unctionalG enomics groupisexpanding in order to carry out its mission ofapplying genetic screens and other functional genomic technolog ie s todiscover and validate novel therapeutic targets .The successfulF unctionalG enomicscandidate willutilize the latest technologies to advance our therapeutic research and discovery efforts .Expertise shouldincludetheuse ofhigh throughputgene editingtechnologiesandnext generation sequencingto assessgenomic functions .The position requires adaptability, creativity, and a capacity for constant innovation in pursuit of company goals.Responsibilities will depend onthe applicant's skillsbutmayinclude :Designand execut eCRISPR and/or RNAi screens tofor target identification, MOA characterizationand other functional characterizations .Developphenotypicand functionalscreening assays in collaboration withcross-functional teamsby generating cell lines, developing lentivirallibraries,andutilizing RNP basedtransfectionstostudygenetic variantsin the context of disease biology.Perform pooled and arrayedbasedgene editingscreens withgenomics-basedassays( RNAseq ,scRNA -seq)and data analysis (R or Python) .Work with NGS and bioinformatics scientists to process genomic samples, analyze screening results, and generate screening hits for follow-up studies.Design and perform tilinggene editingscreens to identify causal SNPs and genes from GWAS human genetic studies .D esign, develop, execute, and analyze experimental research projects in collaboration with cross-functional teamsand contract research organizations.PreferredExperienceDesign and execut ionof cellular studies and screens usingCRISPR/Cas9, RNAi, or other genomic perturbation techniques .Experience withcellularmodels of disease utilizing techniques such ashESC / hiPSCdifferentiationandorganoidcultures.G eneration and interpretation ofepigeneticdatasets (ATAC-seq,ChIP -se q, SELEX-seq )andmassively parallel reporter assaysfor mapping regulatory elements.Working knowledge in genomics technology (NGS, RNA-seq , single cell seq)andwith theuse of liquid handling roboticsforcell cultureorNGSlibrary preparation is preferred.Priorlaboratoryexperience withmammalian cell culture , cell andmolecular biology and biochemical techniques .EducationPh.D.in Molecular/CellBiology, Genomics, Bioengineering, or related discipline withpost - doctoralresearch experience ineitheran academicorindustry lab.Strong analytical, written, and verbal communication skills .Track record of productivity and effectiveprojects.Stronginterestimplementingnewlaboratory techniques and protocols .Attention to detail, time managemen t and organization skills are critical.-BIO

Keywords: BioMarin Pharmaceutical Inc., San Rafael , Scientist I / II, Functional Genomics, Research, Other , San Rafael, California