Senior Research Associate I: Cell Culture
Company: BioMarin Pharmaceutical Inc.
Location: San Rafael
Posted on: May 14, 2022
Job Description:
BioMarin is the world leader in delivering therapeutics that
provide meaningful advances to patients who live with serious and
life-threatening rare genetic diseases. We target diseases that
lack effective therapies and affect relatively small numbers of
patients, many of whom are children. These conditions are often
inherited, difficult to diagnose, progressively debilitating and
have few, if any, treatment options. BioMarin will continue to
focus on advancing therapies that are the first or best of their
kind. BioMarin's Research & Development group is responsible for
everything from research and discovery to post-market clinical
development. Research & Development involves all bench and clinical
research and the associated groups that support those endeavors.
Our teams work on developing first-in-class and best-in-class
therapeutics that provide meaningful advances to patients who live
with rare diseases. Come join our team and make a meaningful impact
on patients' lives. Responsibilities
- Perform routine cell culture as well as viral (AAV/LV) and
non-viral modification of adherent, suspension, iPSC-derived and
primary cell lines
- Design, modify, and clone DNA constructs for expression of
proteins and fusion proteins in mammalian expression systems
- Perform standard molecular biology techniques including DNA
extraction, RNA extraction, and PCR/ddPCR
- Apply basic biochemical and immunological techniques, including
protein extraction, protein gel electrophoresis, conventional and
capillary western blotting, ELISA, and flow cytometry
- Perform routine molecular biology techniques using the
engineered cell lines to support development of new next-generation
sequencing (NGS) assays for sequence determination, editing
efficiency analysis, and off-target assessment
- Maintain detailed records of experimental protocols and data in
electronic laboratory notebook in accordance with company
policy
- Effectively collaborate with a fully integrated research team
to facilitate the success of projectsQualifications
- BS or MS in molecular biology, biochemistry, synthetic biology
or relevant biological sciences
- Gene therapy or gene editing experience preferred, including
working knowledge of state-of-the-art technologies utilized in the
field.
- Strong technical background with standard laboratory methods,
including culturing immortalized, iPSC-derived and primary cells;
molecular biology and cloning; (q)PCR; ELISA; intracellular
staining; western blotting; DNA transfection and viral
transduction; flow cytometry or microscopy
- Ability to productively collaborate in cross-functional
teams
- Excellent interpersonal communication and written skills for
presentations, electronic notebook and report writing
- Ability to adapt to new and fast-paced environment and navigate
uncertainties
- Willingness to embrace new challenges, fearlessly innovate and
constantly learn PLEASE NOTE: Absent a Medical or Religious reason
that prohibits vaccinations, all our incoming employees must be
vaccinated for COVID-19. We are an equal opportunity employer and
all qualified applicants will receive consideration for employment
without regard to race, color, religion, gender, gender identity,
sexual orientation, national origin, disability status, protected
veteran status, or any other characteristic protected by law.
Keywords: BioMarin Pharmaceutical Inc., San Rafael , Senior Research Associate I: Cell Culture, Other , San Rafael, California
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