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Senior Research Associate II

Company: Ivory Systems
Location: San Rafael
Posted on: June 19, 2022

Job Description:

Department: Translational BiologyJob Category: ResearchJob Title: SRA IIDuties: BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.BioMarin's Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. Come join our team and make a meaningful impact on patients' lives.The Cardiovascular Cell Biology group at BioMarin is seeking a SRA2 with experience in modeling cardiovascular disease using a broad range of in vitro models, particularly in the context of evaluating novel therapeutic approaches using gene-edited or patient-derived iPSC lines. This position provides ample opportunities to be part of highly impactful Teams, with opportunities for career growth in a friendly, collaborative, and passionate research environment.He/She is a highly motivated and driven cell biologist with experience in iPS cardiomyocyte differentiation, who develops approaches to model human cardiovascular disease "in a dish" for new and existing internal cardiac projects. The successful candidate will often take on the Cell Biology Functional Lead role in Team-based projects and therefore must be able to work collaboratively. The successful candidate will be a proactive self-starter, with clear passion to progress Her/His in vitro technical scientific skills, generate highly impactful data, and an ability to thrive in a fast-paced collaborative team environment. He/She will communicate scientific findings at Team Meetings, as well as at several forums throughout the company. She/He will partner closely with research associates, senior research associates and scientists within the cardiovascular research group, and other functional groups within Research to support the discovery and pre-clinical development of a wide-range of therapeutic modalities. This is a full-time lab-based position.RESPONSIBILITIESTakes on a leadership role to bring in new technical skills, leads the development, evaluation, and implementation of state-of-the-art cell-based disease models to identify novel therapeutic interventions. This exploratory cell biology work will contribute to our understanding of the mechanisms of cardiac disease pathogenesis, and will also provide preclinical proof-of-concept data to guide in the development of novel and safe therapeutics for inherited cardiac diseases with unmet need.Work as the in vitro Team lead in the development of a novel therapeutic for an inherited cardiac disease.Perform cell biology work, publish findings in high-impact journals and present research at major conferences.Effectively partner with the program team, other SRAs and scientists to develop and execute on the program's strategic plan.Present program data at a range of internal forums, including Research Seminars.Work closely as part of a highly focused and passionate team of in vitro cardiovascular scientists Lead or contribute to study synopses, protocols, study reports and publications arising from Team projects.Skills:Experience with expanding, differentiating and characterizing gene-edited or patient iPSC-derived cardiomyocytes, and modeling human cardiovascular disease "in a dish" is preferable.Excellent working cell biology experience in at least one of the following: functional cardiomyocyte assays, experience with culturing iPS-derived cardiomyocytes, isolation and maintenance of primary cardiac cells, monitoring cardiac cell function with cardio xCELLigence or by high speed calicum imaging, confocal microscopy, force traction microscopy, high content microscopy, live cell imaging, DNA editing.Excellent written and verbal communication skills.Education: Required: A Master's degree with strong experience in cardiovascular research and cardiovascular physiology, pharmacology or a related subject area.Education & Experience Level:MS with 1+ year of industry experience; BS with 5+ years. Very strong technical and analytical skills. Must be a team player.# of Positions: 1Location:San Rafael, CA790 Lindaro Street, Schedule:Start Date: 06/15/2022Estimated End Date: 06/15/2023Hours Per Week: 40.00Hours Per Day: 8.00

Keywords: Ivory Systems, San Rafael , Senior Research Associate II, Other , San Rafael, California

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